NetworkEvolution plugin

The NetworkEvolution plugin is a tool for interactive comparative analysis of networks across different species. Our primary goal here is to allow the user to walk step-by-step through the process of evolution of a selected network module. This process possibly includes protein duplications, losses and speciation, as well as the emergence or deletion of network links. Parent-child and sibling-sibling relationships between homologous proteins are also taken into account and color-coded to allow visual interpretation. Standard input data is provided by the CAPPI procedure (Dutkowski and Tiuryn, Bioinformatics 2007). The data includes the species tree, protein family trees, reconstructed interaction networks and experimentally identified interactions.
It is an open source application (GPL 3 license). The plugin jar file, instructions and sources are available at: http://bioputer.mimuw.edu.pl/modevo.
Please don't hesitate to contact us with any comments and suggestion or if you are interested in co-developing this software.

About the authors

This plugin was implemented by Michal Wozniak. Project idea and guidance came from Janusz Dutkowski and Jerzy Tiuryn.
Affiliation: Institute of Informatics, University of Warsaw
E-mail: {m.wozniak,januszd,tiuryn}@mimuw.edu.pl